Effects of 3,3'4)ihydroxy-a,/j-diethylstilbene And 3,3 ',4,5'-tetrahydroxystilbene On Microtubule Assembly In Vitro, Aneuploidy Induction, And Cellular Microtubule And Actin Networks

Yumiko Sakakibara, Izumi Saito, Taiko Oda, Hiroshi Tsujibo, Yoshihiko Inamori, Yoshihiro Sato

研究成果: Article査読

6 被引用数 (Scopus)

抄録

We examined the inhibitory activities of 3,3'-dihydroxy-a,/J-diethylstilbene (DDS) and 3,3 ',4,5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese hamster V79 cells. DDS showed half the inhibitory activity of diethylstilbestrol (DES) on microtubule assembly in vitro, while THS had none of the inhibitory activity. DDS induced tetraploid at 30 /im, whereas THS was found to be inactive. Furthermore, DDS disturbed cellular microtubule networks at 100 pm. We also examined the effects of DES, DDS and THS on cellular actin networks in mouse BALB 3T3 cells. DES induced a change of actin stress fiber distribution and THS had similar activity, while DDS showed no activity.

本文言語English
ページ(範囲)2115-2119
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
40
8
DOI
出版ステータスPublished - 1992 1 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

フィンガープリント

「Effects of 3,3'4)ihydroxy-a,/j-diethylstilbene And 3,3 ',4,5'-tetrahydroxystilbene On Microtubule Assembly In Vitro, Aneuploidy Induction, And Cellular Microtubule And Actin Networks」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル