Effects of a Thromboxane Synthetase Inhibitor (OKY-046) in an Ischemia-Reperfusion Model of Intrauterine Growth Retardation in Sprague-Dawley Rats

Mamoru Tanaka, Michiya Natori, Hitoshi Ishimoto, Kei Miyakoshi, Toyohiko Miyazaki, Toshifumi Kobayashi, Yasunori Yoshimura

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We investigated the effects of thromboxane (TX) A2 in rats with ischemia-reperfusion-induced intrauterine growth retardation. A saline solution or OKY-046, a selective TXA2 synthetase inhibitor, was injected into the caudal vein of pregnant rats on gestation day 17 before the induction of 60-min uteroplacental ischemia. The fetuses and placentas were delivered and examined on gestation day 21. Blood from the uterine vein of the occluded horn shortly after uteroplacental ischemia was collected, and plasma concentrations of TXB2 and 6-keto-prostaglandin (PG) F were determined in the other rats on gestation day 17. Treatment with OKY-046 prevented the ischemia-induced reduction in the fetal body and placental weights. The ratio of 6-keto-PGFια to TXB2 was significantly increased in the OKY-046-treated group. We conclude that the action of TXA2 might play a salient role in our model.

本文言語English
ページ(範囲)181-186
ページ数6
ジャーナルNeonatology
72
3
DOI
出版ステータスPublished - 1997

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 発生生物学

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