Effects of anion exchange resin as phosphate binder on serum phosphate and iPTH levels in normal rats

Hiroyoshi Inoue, M. Kagoshima, K. Kaibara

研究成果: Article査読

6 被引用数 (Scopus)

抄録

In order to investigate the characteristics of anion exchange resins that may safely and effectively bind dietary phosphate in digestive tract, phosphate binding experiments were carried out in vitro and in vivo with normal rats by comparing anion exchange resins, PAA-B (which has the same chemical structure as Sevelamer® HCl) and Dowe 1x8, with CaCO3. In in vitro phosphate binding experiments, PAA-B bound 32.3% less phosphate than CaCO3 at pH 7. In the rat dietary phosphorus excretion experiments, PAA-B, Dowex 1x8, and CaCO3 increased fecal phosphorus excretion by 62.7, 32.3, and 84.0%, respectively. Famotidine significantly reduced the phosphate binding of CaCO3. When phosphate solution was orally administered, PAA-B depressed serum phosphorus augmentations immediately after administration and thereafter effectively depressed serum iPTH. This suggests that anion exchange resins with most primary and secondary amino type anion exchange groups, have bright prospects in the treatment of hyperphosphatemia.

本文言語English
ページ(範囲)243-249
ページ数7
ジャーナルInternational Journal of Artificial Organs
23
4
DOI
出版ステータスPublished - 2000 4月
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学

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