Effects of Carbon Black Nanoparticles on Elastase-Induced Emphysematous Lung Injury in Mice

Ken ichiro Inoue, Rie Yanagisawa, Eiko Koike, Ryosuke Nakamura, Takamichi Ichinose, Sadatomo Tasaka, Masako Kiyono, Hirohisa Takano

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Although adverse health effects of particulate matter with a diameter of <100nm (nanoparticles) have been proposed, biological evidence supporting their promotion of the inflammatory lung response in vivo is limited. This study investigated the impact of pulmonary exposure to carbon black nanoparticles (CBNP) on emphysematous lung injury induced by porcine pancreatic elastase (PPE) in mice. Vehicle, two sizes (14 and 56nm) of CBNP (50μg/body: 4mg/kg), PPE (0.03U/body: 1U/kg) or PPE+CBNP was administered intratracheally; thereafter, parameters of inflammatory lung changes were evaluated at several time-points. CBNP of 14nm significantly induced acute lung inflammation in non-elicited subjects and aggravated PPE-elicited airway neutrophilic inflammation at an early stage (day 1), which was concomitant with the enhanced lung expression of pro-inflammatory cytokines such as interleukin-1β and chemokine such as keratinocyte-derived chemoattractant. Further, 14-nm CBNP exaggerated emphysematous lung structural changes at a delayed stage (day 14). On the other hand, 56-nm CBNP induced lung inflammation but did not influence PPE-elicited pathophysiology in the lung. Taken together, CBNP at an optimal size and dose can exacerbate PPE-induced pulmonary inflammation and emphysema. This enhancement may be mediated, at least partly, via the increased local expression of pro-inflammatory molecules.

本文言語English
ページ(範囲)234-240
ページ数7
ジャーナルBasic and Clinical Pharmacology and Toxicology
108
4
DOI
出版ステータスPublished - 2011 4

ASJC Scopus subject areas

  • 毒物学
  • 薬理学

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