Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes

Medicine & Life Sciences

• Rabeprazole 100%
• Cytochrome P-450 CYP2C19 87%
• rabeprazole-thioether 86%
• Clarithromycin 78%
• Verapamil 70%
• Pharmacokinetics 49%
• Genotype 47%
• Cytochrome P-450 CYP3A 15%
• Area Under Curve 10%
• Cytochrome P-450 CYP3A Inhibitors 9%
• Placebos 9%
• Sulfides 8%
• Proton Pump Inhibitors 7%
• ATP Binding Cassette Transporter, Subfamily B, Member 1 7%
• Cross-Over Studies 6%
• Volunteers 5%
• Acids 4%