Effects of exercise on residual renal function in patients undergoing peritoneal dialysis: A post-hoc analysis of a randomized controlled trial

Kiyotaka Uchiyama, Naoki Washida, Kohkichi Morimoto, Kaori Muraoka, Takashin Nakayama, Keika Adachi, Takahiro Kasai, Kazutoshi Miyashita, Shu Wakino, Hiroshi Itoh

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We aimed to investigate the effects of exercise on renal outcomes in patients undergoing peritoneal dialysis (PD). In a post-hoc analysis of a randomized controlled trial of a 12-week home-based exercise program involving 47 patients undergoing PD, we excluded 18 patients with anuria and analyzed 13 and 16 patients in the usual care and exercise groups, respectively. The primary outcomes were weekly renal creatinine clearance (CCr) and urinary biomarkers: liver-type fatty acid-binding protein (L-FABP) and the microalbumin-to-creatinine ratio (ACR). Although the maintenance of weekly renal CCr in the exercise group was not significantly different compared with that in the usual care group (P =.09), urinary L-FABP levels (P =.02) and ACR (P =.04) were significantly decreased in the exercise group. To the best of our knowledge, this is the first study to demonstrate the beneficial effects of exercise on renal outcomes in patients undergoing PD.

本文言語English
ページ(範囲)668-676
ページ数9
ジャーナルTherapeutic Apheresis and Dialysis
24
6
DOI
出版ステータスPublished - 2020 12

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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