Effects of family history on inflammatory bowel disease characteristics in Japanese patients

Erika Kuwahara, Keiko Asakura, Yuji Nishiwaki, Nagamu Inoue, Mamoru Watanabe, Toshifumi Hibi, Toru Takebayashi

研究成果: Article査読

24 被引用数 (Scopus)


Background Although the prevalence of inflammatory bowel disease (IBD) is reported to have reached a plateau in Western countries, it is increasing in Asia. The etiology of IBD is still under investigation. We performed an epidemiological study to clarify the characteristics of IBD in Japan, focusing on patients' family history. Methods We obtained clinical data on ulcerative colitis (UC) (46,114 cases) and Crohn's disease (CD) (11,305 cases) in 2007 from an electronic database maintained under the Japanese Ministry of Health, Labour and Welfarés nationwide registry system, and analyzed the differences in disease characteristics between patients with IBD who had a family history of the disease and those who did not. Results A total of 2.7% of the patients with UC and 2.6% of those with CD had a family history. The present age and age at disease onset were lower among the patients with UC who had a family history than among those without (present age: p\0.001; age at disease onset: p\0.001; Mann-Whitney U-test), but no similar trend was observed in the patients with CD. Disease severity was worse among both the UC and CD patients with a family history. The clinical course of patients with UC was not affected by family history. Levels of independence in daily life were associated with family history among CD patients, whereas age was associated with levels of independence in daily life among UC patients. Conclusion Disease characteristics of IBD vary in some aspects according to the presence or absence of a family history.

ジャーナルJournal of gastroenterology
出版ステータスPublished - 2012 9

ASJC Scopus subject areas

  • 消化器病学


「Effects of family history on inflammatory bowel disease characteristics in Japanese patients」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。