Effects of gonadotropin-releasing hormone agonist (GnRHa) and ovariectomy on leukocyte subpopulations in rats with autotransplanted endometrium

Hidehiko Matsubayashi, Ken Ichi Iwasaki, Tetsuo Maruyama, Nobuaki Ozawa, Taiko Nemoto, Shinya Iwasaki, Wen Shu Sun, Kazumi Nakazawa, Shiro Nozawa, Tsunehisa Makino

研究成果: Article査読

1 被引用数 (Scopus)

抄録

PROBLEM: To determine the effect of estrogen deficiency on populations of immune cells in rats with autotransplanted endometrium. METHOD OF STUDY: Autologous endometrial segments were implanted in the peritoneum of rats. Leukocyte subsets in the peripheral blood (PB) and peritoneal fluid (PF) of autotransplanted rats treated with gonadotropin-releasing hormone agonist (GnRHa) or ovariectomy were analyzed by flow cytometry. RESULTS: Endometrial growth was suppressed in association with increases in natural killer (NK) cells and macrophages in rats treated surgically or medically after endometrial implantation compared with autotransplanted-only rats. Normal rats treated with GnRHa showed no significant alterations in PB and PF leukocyte subsets, even in NK cells and macrophages, compared with untreated normal rats. CONCLUSIONS: Data suggest that GnRHa itself did not have an immunomodulating effect when rats were treated for 3 weeks, but that a hypoestrogenic state reduced the size of the ectopic endometrium in association with increases in NK cells and macrophages. Our findings support the hypothesis that ectopic endometrial cells may release immunosuppressive factors.

本文言語English
ページ(範囲)40-48
ページ数9
ジャーナルAmerican Journal of Reproductive Immunology
36
1
DOI
出版ステータスPublished - 1996 7

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 生殖医学
  • 産婦人科学

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