Effects of high linear energy transfer radiation on the cochlea of C3H/He mouse during postnatal developmental course

Yumiko Nitta, Nobukazu Araki, Kohsaku Nitta, Toshihide Harada, Fumiko Ishizaki, Juko Ando

研究成果: Article

4 引用 (Scopus)

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To investigate the biological effectiveness of neutrons at energies below 1MeV with regard to ear toxicity, we exposed mice to 1.0 Gy of monoenergetic neutrons (1.026 MeV) or 137Cs gamma rays at 7 days of age, and observed subsequent morphological changes in the inner ear with light and scanning electron microscopes. Monoenergetic neutrons, but not gamma rays, caused acute changes in the ear. The epithelium of the greater epithelial ridge in the organ of Corti showed degeneration around 6 hours and disappeared by 72 hours post-irradiation. The apoptotic cell death of the epithelium of the greater epithelial ridge was inducible by the radiation at 3 or 4 days of age. The hair cells formed the protrusion structures of the surface by 72 hours post-irradiation. Neutron-irradiation also caused acute otitis media until 10 weeks of age.

元の言語English
ページ(範囲)75-81
ページ数7
ジャーナルJournal of radiation research
46
発行部数1
DOI
出版物ステータスPublished - 2005 3

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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