Effects of high salt intake on dopamine production in rat kidney

M. Hayashi, Y. Yamaji, W. Kitajima, T. Saruta

研究成果: Article査読

36 被引用数 (Scopus)

抄録

To examine the origin of increased urinary dopamine excretion (U(DA)V) during high salt intake, we measured U(DA)V from the innervated (INN) or the chronically denervated (DEN) kidney in rats fed either a high-salt (HS) or low-salt (LS) diet. U(DA)V of DEN [3.50 ± 0.46 ng· min-1·inulin clearance (C(IN))-1] and INN (4.00 ± 0.59 ng· min-1·C(IN)-1) kidneys in the HS group showed a significant increase compared with that of the respective kidney in the LS group (DEN 1.42 ± 0.12, INN 1.44 ± 0.09 ng·min-1·C(IN)-1), whereas the effect of denervation on U(DA)V was not significantly different between two groups. We determined aromatic L-amino acid decarboxylase (L-AADC) activity and dopamine degradation rate of microdissected proximal convoluted tubules to study the changes in dopamine metabolism. L-AADC activity in the HS group showed a significant increase compared with that in the LS group, although there was no significant change in dopamine degradation rate. We conclude that the increase in U(DA)V during high salt intake was mainly caused by the enhancement of extraneural dopamine production by the kidney in rats. Dopamine-producing enzyme, but not its degradation in the tubular cells, plays a role in the regulation of extraneural dopamine production.

本文言語English
ページ(範囲)E675-E679
ジャーナルAmerican Journal of Physiology - Endocrinology and Metabolism
260
5 23-5
DOI
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生理学
  • 生理学(医学)

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