Effects of Long-Chain Fatty Acids and Fatty Alcohols on the Growth of Streptococcus mutans

Masao Hattori, Kumi Miyachi, Sumitra Hada, Nobuko Kakiuchi, Tsuneo Namba, Fumiyuki Kiuchi, Yoshisuke Tsuda

研究成果: Article

19 引用 (Scopus)

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Minimal inhibitory concentrations (MICs) of a series of fatty acids and fatty alcohols against a cariogenic bacterium, Streptococcus mutans, were determined by a tube dilution technique. Among saturated fatty alcohols, tetradecanol and pentadecanol had the highest activity (MIC, 1.56μg/ml), while among monounsaturated fatty alcohols, 10Z-pentadecenol had the strongest activity (MIC, 0.78μg/ml). Saturated fatty acids showed relatively weak activity; tridecanoic acid had the highest activity among them (MIC, 12.5μg/ml). Among unsaturated fatty acids, 10Z-heptadecenoic 6Z-octadecenoic, 11Z-octadecenoic and 9Z,12Z-octadecadienoic acids had potent activity (MIC, 3.13 μg/ml). The antibacterial activities of methyl-branched and hydroxyl fatty acids as well as long chain dicarboxylic acids were also investigated.

元の言語English
ページ(範囲)3507-3510
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
35
発行部数8
DOI
出版物ステータスPublished - 1987 1 1
外部発表Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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