Effects of neuropeptide Y on cochlear blood flow in guinea pigs

M. Itou, K. Ogawa, Y. Inoue, M. Sato, J. Kanzaki

研究成果: Article

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The aim of this study was to clarify the effects of neuropeptide Y (NPY) on cochlear blood flow (CBF) in pigmented guinea pigs. NPY was administered with or without noradrenaline (NA) by systemic perfusion or perilymphatic local perfusion, and CBF was measured using a laser Doppler flowmeter. The systemic and perilymphatic administrations of NPY with NA induced greater prolongation of the increase in and recovery of CBF than the administration of NA or NPY alone. Continuous reduction in CBF induced by NPY may play an important role in the pathogenesis of stress-induced sensorineural hearing losses, such as sudden deafness.

元の言語English
ページ(範囲)573-578
ページ数6
ジャーナルActa Oto-Laryngologica
121
発行部数5
DOI
出版物ステータスPublished - 2001 1 1

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ASJC Scopus subject areas

  • Otorhinolaryngology

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