Effects of nimodipine (Bay e 9736) on cerebral circulation in cats

K. Tanaka, F. Gotoh, F. Muramatsu, Y. Fukuuchi, T. Amano, H. Okayasu, N. Suzuki

研究成果: Article査読

37 被引用数 (Scopus)

抄録

The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).

本文言語English
ページ(範囲)1494-1497
ページ数4
ジャーナルArzneimittel-Forschung/Drug Research
30
9
出版ステータスPublished - 1980 11 10

ASJC Scopus subject areas

  • 創薬

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