Effects of organic solvents on drug incorporation into polymeric carriers and morphological analyses of drug-incorporated polymeric micelles

Yoshiko Harada, Tatsuhiro Yamamoto, Masaru Sakai, Toshiharu Saiki, Kumi Kawano, Yoshie Maitani, Masayuki Yokoyama

    研究成果: Article査読

    18 被引用数 (Scopus)

    抄録

    We incorporated an anticancer agent, camptothecin (CPT), into polymeric micelle carriers by using two different solvents (TFE and chloroform) in the solvent-evaporation drug incorporation process. We observed significant differences in the drug-incorporation behaviors, in the morphologies of the incorporated drug and the polymeric micelles, and in the pharmacokinetic behaviors between the two solvents' cases. In particular, the CPT-incorporated polymeric micelles prepared with TFE as the incorporation solvent exhibited more stable circulation in blood than those prepared with chloroform. This contrast indicates a novel technological perspective regarding the drug incorporation into polymeric micelle carriers. Morphological analyses of the inner core have revealed the presence of the directed alignment of the CPT molecules and CPT crystals in the micelle inner core. This is the first report of the morphologies of the drug incorporated into the polymeric micelle inner cores. We believe these analyses are very important for further pharmaceutical developments of polymeric micelle drug-carrier systems.

    本文言語English
    ページ(範囲)271-280
    ページ数10
    ジャーナルInternational Journal of Pharmaceutics
    404
    1-2
    DOI
    出版ステータスPublished - 2011 2 14

    ASJC Scopus subject areas

    • Pharmaceutical Science

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