Effects of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes, Japan, 2010–2017

Invasive Pneumococcal Diseases Surveillance Study Group

研究成果: Article

15 引用 (Scopus)

抄録

To clarify year-to-year changes in capsular serotypes, resistance genotypes, and multilocus sequence types of Streptococcus pneumoniae, we compared isolates collected from patients with invasive pneumococcal disease before and after introductions of 7-and 13-valent pneumococcal conjugate vaccines (PCV7 and PVC13, respectively). From April 2010 through March 2017, we collected 2,856 isolates from children and adults throughout Japan. Proportions of PCV13 serotypes among children decreased from 89.0% in fiscal year 2010 to 12.1% in fiscal year 2016 and among adults from 74.1% to 36.2%. Although nonvaccine serotypes increased after introduction of PCV13, genotypic penicillin resistance decreased from 54.3% in 2010 to 11.2% in 2016 among children and from 32.4% to 15.5% among adults. However, genotypic penicillin resistance emerged in 9 nonvaccine serotypes, but not 15A and 35B. Multilocus sequence typing suggested that resistant strains among nonvaccine serotypes may have evolved from clonal complexes 156 and 81. A more broadly effective vaccine is needed.

元の言語English
ページ(範囲)2010-2020
ページ数11
ジャーナルEmerging Infectious Diseases
24
発行部数11
DOI
出版物ステータスPublished - 2018 11 1

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Penicillin Resistance
Conjugate Vaccines
Pneumococcal Vaccines
Japan
Multilocus Sequence Typing
Streptococcus pneumoniae
Vaccines
Genotype
Serogroup

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

これを引用

Effects of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes, Japan, 2010–2017. / Invasive Pneumococcal Diseases Surveillance Study Group.

:: Emerging Infectious Diseases, 巻 24, 番号 11, 01.11.2018, p. 2010-2020.

研究成果: Article

Invasive Pneumococcal Diseases Surveillance Study Group. / Effects of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes, Japan, 2010–2017. :: Emerging Infectious Diseases. 2018 ; 巻 24, 番号 11. pp. 2010-2020.
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