Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

Mikiko Shimizu, Tsukasa Uno, Kazunobu Sugawara, Tomonori Tateishi

研究成果: Article査読

30 被引用数 (Scopus)

抄録

Aims: We determined whether or not the extent of drug interaction of fexofenadine by itraconazole is time-dependent. Methods: In a randomized two-phase crossover study, itraconazole was administered orally for 6 days, and, on days 1, 3 and 6, fexofenadine was administered simultaneously. On another occasion, fexofenadine was administered alone. Results: Itraconazole increased fexofenadine AUC(0, ∞), and the % change for difference was 178% (95% CI 1235, 3379), 205% (95% CI 1539, 3319) and 169% (95% CI 1128, 2987) on days 1, 3 and 6 of the 6 day treatment, respectively. Conclusions: The extent of drug interaction by itraconazole was not time-dependent.

本文言語English
ページ(範囲)372-376
ページ数5
ジャーナルBritish journal of clinical pharmacology
62
3
DOI
出版ステータスPublished - 2006 9

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)

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