Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities

Shuping Wang, Nanae Shibahara, Daishi Kuramashi, Shinpei Okawa, Naoto Kakuta, Eiji Okada, Atsushi Maki, Yukio Yamada

    研究成果: Article査読

    14 被引用数 (Scopus)

    抄録

    In order to investigate the effects of anatomical variation in human heads on the optical mapping of brain activity, we perform simulations of optical mapping by solving the photon diffusion equation for layered-models simulating human heads using the finite element method (FEM). Particularly, the effects of the spatial variations in the thicknesses of the skull and cerebrospinal fluid (CSF) layers on mapping images are investigated. Mapping images of single active regions in the gray matter layer are affected by the spatial variations in the skull and CSF layer thicknesses, although the effects are smaller than those of the positions of the active region relative to the data points. The increase in the skull thickness decreases the sensitivity of the images to active regions, while the increase in the CSF layer thickness increases the sensitivity in general. The images of multiple active regions are also influenced by their positions relative to the data points and by their depths from the skin surface.

    本文言語English
    ページ(範囲)410-420
    ページ数11
    ジャーナルOptical Review
    17
    4
    DOI
    出版ステータスPublished - 2010 8 5

    ASJC Scopus subject areas

    • 原子分子物理学および光学

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