Effects of sucralfate on gastric irritant-induced necrosis and apoptosis in cultured guinea pig gastric mucosal cells

Tatsuya Hoshino, Tatsunori Takano, Wataru Tomisato, Shinji Tsutsumi, Hyun Jung Hwang, Yuko Koura, Kiyo Nishimoto, Tomofusa Tsuchiya, Tohru Mizushima

研究成果: Article

6 引用 (Scopus)

抜粋

We previously reported that several gastric irritants, including ethanol, hydrogen peroxide, and hydrochloric acid, induced both necrosis and apoptosis in cultured gastric mucosal cells. In the present study, we examined the effects of sucralfate, a unique gastroprotective drug, on gastric irritant-induced necrosis and apoptosis produced in vitro. Sucralfate strongly inhibited ethanol-induced necrosis in primary cultures of guinea pig gastric mucosal cells. The preincubation of cells with sucralfate was not necessary for its cytoprotective effect to be observed, thus making its mechanism of action different from that of other gastroprotective drugs. Necrosis of gastric mucosal cells induced by hydrogen peroxide or indomethacin was also suppressed by sucralfate. On the other hand, sucralfate only weakly inhibited ethanol-induced apoptosis. These results suggest that the cytoprotective effect of sucralfate on gastric mucosa in vivo can be explained, at least in part, by its inhibitory effect on gastric irritant-induced necrosis.

元の言語English
ページ(範囲)24-27
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
26
発行部数1
DOI
出版物ステータスPublished - 2003 1 1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

フィンガープリント Effects of sucralfate on gastric irritant-induced necrosis and apoptosis in cultured guinea pig gastric mucosal cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Hoshino, T., Takano, T., Tomisato, W., Tsutsumi, S., Hwang, H. J., Koura, Y., Nishimoto, K., Tsuchiya, T., & Mizushima, T. (2003). Effects of sucralfate on gastric irritant-induced necrosis and apoptosis in cultured guinea pig gastric mucosal cells. Biological and Pharmaceutical Bulletin, 26(1), 24-27. https://doi.org/10.1248/bpb.26.24