Efficacy and safety of bucillamine, a D-penicillamine analogue, in patients with active rheumatoid arthritis

Naoya Sekiguchi, Hideto Kameda, Koichi Amano, Tsutomu Takeuchi

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Japanese rheumatologists consider bucillamine (Buc) to be a useful disease-modifying antirheumatic drug (DMARD) and often give Buc to patients with rheumatoid arthritis (RA) prior to administering methotrexate (MTX). However, no large studies on the efficacy and safety of Buc in RA patients have been published in English to date. We therefore investigated the clinical course of RA patients treated with Buc and compared the results with those for patients treated with MTX to evaluate and confirm the place of Buc in therapeutic strategies for RA in Japan. Our results suggested that Buc should be given to patients with moderately active RA either before or after the administration of MTX because its efficacy can be judged within 3 months and because serious adverse events are rare. Issues like the ability of Buc to prevent joint destruction and its efficacy and safety when combined with agents like etanercept require future study.

本文言語English
ページ(範囲)85-91
ページ数7
ジャーナルModern rheumatology
16
2
DOI
出版ステータスPublished - 2006 4 1
外部発表はい

ASJC Scopus subject areas

  • リウマチ学

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