Efficacy of photodynamic inactivation against Pseudomonas aeruginosa with pulsed light and CW light excitation

Tohru Yamaguchi, Shunichi Sato, Satoko Kawauchi, Mitsuhiro Terakawa, Nariyoshi Shinomiya, Daizoh Saitoh, Hiroshi Ashida, Minoru Obara

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

We compared methylene blue (MB)-mediated photobactericidal efficacies against Pseudomonas aeruginosa when using nanosecond pulsed light and CW light. In the intensity range of 10-200 mW/cm 2, there was no significant difference between two cases, while photobactericidal efficacy with nanosecond pulsed light was significantly lower than that with CW light at an intensity of 250 mW/cm 2. This is attributable to the saturated absorption of MB molecules due to high peak intensity of nanosecond pulsed light. On the basis of these results, we estimated the depth dependence of bacterial killing, showing that in the skin tissue region deeper than 1.5 mm, photobactericidal efficacy with nanosecond pulsed light was higher than that with CW light. This suggests that the advantage of using high-peak-intensity pulsed light for deep tissue treatment.

本文言語English
ホスト出版物のタイトルOptical Methods for Tumor Treatment and Detection
ホスト出版物のサブタイトルMechanisms and Techniques in Photodynamic Therapy XV
DOI
出版ステータスPublished - 2006 6 30
外部発表はい
イベントOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV - San Jose, CA, United States
継続期間: 2006 1 212006 1 22

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
6139
ISSN(印刷版)1605-7422

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
CountryUnited States
CitySan Jose, CA
Period06/1/2106/1/22

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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