Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies

Juntaro Matsuzaki, Hidekazu Suzuki, Toshihiro Nishizawa, Kenro Hirata, Hitoshi Tsugawa, Yoshimasa Saito, Sawako Okada, Seiichiro Fukuhara, Toshifumi Hibi

研究成果: Article査読

48 被引用数 (Scopus)

抄録

Sitafloxacin-based triple therapy achieved 83.6% (per-protocol) and 78.2% (intention-to-treat) success in eradicating Helicobacter pylori among 78 Japanese patients after clarithromycin-based first-line and metronidazole-based second-line triple therapies failed. Eradication succeeded in 32 out of 43 patients, even with gyrA mutation-positive Helicobacter pylori (per protocol). The position of the gyrA mutation (N87 or D91) was determined to be a better marker than MIC levels for predicting outcomes of sitafloxacin-based treatment.

本文言語English
ページ(範囲)1643-1645
ページ数3
ジャーナルAntimicrobial Agents and Chemotherapy
56
3
DOI
出版ステータスPublished - 2012 3月

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

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