Efficacy of tegafur-uracil (UFT) administration in castration-resistant prostate cancer patients with a history of both alternative antiandrogen therapy and estramustine phosphate sodium hydrate therapy

Nozomi Hayakawa, Kazuhiro Matsumoto, Atsuko Sato, Hirofumi Sakamoto, Taisuke Ezaki, Takahiro Maeda, Akiharu Ninomiya, So Nakamura

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Purpose: The purpose of this study was to evaluate the efficacy of tegafur-uracil (UFT) administration as a fourth-line therapy in patients with castration-resistant prostate cancer (CRPC) who had already received combined androgen blockade (CAB) therapy (first-line), alternative antiandrogen therapy (second-line), and estramustine phosphate sodium hydrate (EMP) therapy (third-line), in order to determine who would benefit from UFT therapy. Methods: UFT was administered at a daily dose of 300 mg/m2 to 26 patients, and the response to UFT 4 weeks after its induction and its toxicity were evaluated. Results: A reduction in the serum prostate-specific antigen (PSA) value was observed in 12 patients (46.2 %), while two cases (7.7 %) achieved more than 50 % reduction in PSA. Two patients (7.7 %) required discontinuation of UFT administration because of side effects (grade 2 exanthema in one patient and grade 2 nausea in one patient). A PSA response to UFT was observed, especially in patients older than 75 years and/or whose Gleason score was 8 or less. Conclusions: Our data indicate that UFT administration as a fourth-line therapy was tolerable and effective to some degree in patients with CRPC who had already received CAB therapy, alternative antiandrogen therapy, and EMP therapy. It can be used, even in patients aged more than 75 years old, without any loss of efficacy or effect on their activities of daily life, and can be regarded as a treatment option for patients with advanced prostate cancer.

本文言語English
ページ(範囲)1123-1129
ページ数7
ジャーナルInternational Urology and Nephrology
46
6
DOI
出版ステータスPublished - 2014 6
外部発表はい

ASJC Scopus subject areas

  • Nephrology
  • Urology

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