Efficient parameter identification for stochastic biochemical networks using a reduced-order realization

Yutaka Hori, Mustafa H. Khammash, Shinji Hara

研究成果: Conference contribution

5 引用 (Scopus)

抄録

In this paper, we propose a parameter identification method for stochastic biochemical reaction networks using flow cytometry data. A distinctive feature of the proposed method is that it is computationally efficient compared to existing works, thus it is applicable to complex biochemical networks. To this end, we first show that it is possible to construct a significantly small-order realization of the stochastic biochemical system using flow cytometry measurements. Then, the small-order realization is utilized for the development of the efficient identification method. Finally, the proposed method is demonstrated with an existing biological example.

元の言語English
ホスト出版物のタイトル2013 European Control Conference, ECC 2013
ページ4154-4159
ページ数6
出版物ステータスPublished - 2013
外部発表Yes
イベント2013 12th European Control Conference, ECC 2013 - Zurich, Switzerland
継続期間: 2013 7 172013 7 19

Other

Other2013 12th European Control Conference, ECC 2013
Switzerland
Zurich
期間13/7/1713/7/19

Fingerprint

Flow cytometry
Identification (control systems)

ASJC Scopus subject areas

  • Control and Systems Engineering

これを引用

Hori, Y., Khammash, M. H., & Hara, S. (2013). Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. : 2013 European Control Conference, ECC 2013 (pp. 4154-4159). [6669455]

Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. / Hori, Yutaka; Khammash, Mustafa H.; Hara, Shinji.

2013 European Control Conference, ECC 2013. 2013. p. 4154-4159 6669455.

研究成果: Conference contribution

Hori, Y, Khammash, MH & Hara, S 2013, Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. : 2013 European Control Conference, ECC 2013., 6669455, pp. 4154-4159, 2013 12th European Control Conference, ECC 2013, Zurich, Switzerland, 13/7/17.
Hori Y, Khammash MH, Hara S. Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. : 2013 European Control Conference, ECC 2013. 2013. p. 4154-4159. 6669455
Hori, Yutaka ; Khammash, Mustafa H. ; Hara, Shinji. / Efficient parameter identification for stochastic biochemical networks using a reduced-order realization. 2013 European Control Conference, ECC 2013. 2013. pp. 4154-4159
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