Efficient Synthesis of (-)-Hanishin, (-)-Longamide B, and (-)-Longamide B Methyl Ester through Piperazinone Formation from 1,2-Cyclic Sulfamidates

Zenyu Shiokawa, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto

研究成果: Article

8 引用 (Scopus)

抜粋

We describe a simple chiral-pool synthesis of (-)-longamide B, (-)-longamide B methyl ester, and (-)-hanishin. The key feature of the total synthesis is the formation of a piperazinone from a 1,2-cyclic sulfamidate and methyl 2-pyrrolecarboxylate, which permits efficient construction of the pyrrolopiperazinone core scaffold.

元の言語English
記事番号st-2015-u0727-l
ページ(範囲)616-620
ページ数5
ジャーナルSynlett
27
発行部数4
DOI
出版物ステータスPublished - 2016 3 1

ASJC Scopus subject areas

  • Organic Chemistry

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