Eiger and wengen: The drosophila orthologs of TNF/TNFR

Tatsushi Igaki, Hiroshi Kanda, Hideyuki Okano, Tian Xu, Masayuki Miura

研究成果: Conference contribution

8 被引用数 (Scopus)

抄録

Drosophila provides a powerful genetic model for studying the in vivo regulation of biological processes, such as cell proliferation, cell differentiation, and cell death. In a large-scale ectopic-expression screen in Drosophila for identifying genes regulating cell death, the fly homolog of tumor necrosis factor (TNF) encoded by eiger (e da-l i ke cell death trig ger) was identified [7]. eiger was also isolated independently through a molecular approach [15]. eiger encodes a protein of 409 amino acids with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger's TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.

本文言語English
ホスト出版物のタイトルAdvances in TNF Family Research
ホスト出版物のサブタイトルProceedings of the 12th International TNF Conference, 2009
編集者David Wallach, Andrew Kovalenko, Marc Feldmann
ページ45-50
ページ数6
DOI
出版ステータスPublished - 2011 12月 15

出版物シリーズ

名前Advances in Experimental Medicine and Biology
691
ISSN(印刷版)0065-2598

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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