TY - GEN
T1 - Eiger and wengen
T2 - The drosophila orthologs of TNF/TNFR
AU - Igaki, Tatsushi
AU - Kanda, Hiroshi
AU - Okano, Hideyuki
AU - Xu, Tian
AU - Miura, Masayuki
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Drosophila provides a powerful genetic model for studying the in vivo regulation of biological processes, such as cell proliferation, cell differentiation, and cell death. In a large-scale ectopic-expression screen in Drosophila for identifying genes regulating cell death, the fly homolog of tumor necrosis factor (TNF) encoded by eiger (e da-l i ke cell death trig ger) was identified [7]. eiger was also isolated independently through a molecular approach [15]. eiger encodes a protein of 409 amino acids with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger's TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.
AB - Drosophila provides a powerful genetic model for studying the in vivo regulation of biological processes, such as cell proliferation, cell differentiation, and cell death. In a large-scale ectopic-expression screen in Drosophila for identifying genes regulating cell death, the fly homolog of tumor necrosis factor (TNF) encoded by eiger (e da-l i ke cell death trig ger) was identified [7]. eiger was also isolated independently through a molecular approach [15]. eiger encodes a protein of 409 amino acids with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger's TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.
UR - http://www.scopus.com/inward/record.url?scp=79954447953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954447953&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-6612-4_5
DO - 10.1007/978-1-4419-6612-4_5
M3 - Conference contribution
C2 - 21153308
AN - SCOPUS:79954447953
SN - 9781441966117
T3 - Advances in Experimental Medicine and Biology
SP - 45
EP - 50
BT - Advances in TNF Family Research
A2 - Wallach, David
A2 - Kovalenko, Andrew
A2 - Feldmann, Marc
ER -