Ejects of Single and Repeated Treatment with Itraconazole on the Pharmacokinetics of Midazolam in Rats

Yasufumi Sawada, Sayuri Takedomi, Hirotami Matsuo, Hisakazu Ohtani, Katsuhiro Yamano, Tatsuji Iga

研究成果: Article査読

2 被引用数 (Scopus)

抄録

To estimate the influence of repeated administration of drug metabolism inhibitors on the extent of drug interaction, we investigated the ejects of single intravenous or repeated oral administration of itraconazole on the pharmacokinetics of midazolam in rats. In the single administration study, the plasma concentration of itraconazole was maintained by intravenous infusion, and midazolam was administered into the portal vein to investigate its kinetics. In the repeated administration study, the kinetics of midazolam was investigated after seven-day oral treatment with itraconazole. The in vitro metabolism of midazolam and the contents of cytochrome P450 were investigated using liver microsomes from the itraconazole-treated rats.

本文言語English
ページ(範囲)275-283
ページ数9
ジャーナルDrug Metabolism And Pharmacokinetics
17
4
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学
  • 薬理学(医学)

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