Electrophysiological and histological effects on canine right atrium by photosensitization reaction under catheterization in vivo

M. Takahashi, E. Ogawa, S. Motohashi, T. Nakamura, H. Kawakami, N. Machida, A. Ito, T. Kimura, S. Takatsuki, K. Fukumoto, S. Miyoshi, K. Fukuda, T. Arai

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

We investigated electrophysiological and histological effect on canine anatomical isthmus in right atrium by photosensitization reaction (PR) of talaporfin sodium operated via a manipulative 7 Fr. laser catheter to establish a nonthermal tachyarrhythmia treatment. We continuously administrated talaporfin sodium via a left femoral vein to maintain photosensitizer concentration of 25-35 μg/ml in blood plasma, which is within the range of clinical use in human. Fifteen-minute after kickoff of the photosensitizer administration, a 663 nm laser was irradiated via the laser catheter for 30 s/point with irradiance of 10 W/cm2. After 17 times irradiations, a 23 ms delay of the electrical signal propagation along tricuspid annulus was observed. This result might demonstrate the acute electrical conduction delay induced by PR. The canine heart was extracted 10 days after PR and Azan staining specimen was histologically evaluated to investigate the myocardial damage by PR. The transmural fibrosis in anatomical isthmus was found. We demonstrated the PR-induced electrical conduction delay in acute phase in vivo using continuous photosensitizer dosed canine model, which maintain the clinical photosensitizer concentrat.

本文言語English
ホスト出版物のタイトルPhotonic Therapeutics and Diagnostics IX
DOI
出版ステータスPublished - 2013
イベントPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
継続期間: 2013 2 22013 2 7

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
8565
ISSN(印刷版)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics IX
国/地域United States
CitySan Francisco, CA
Period13/2/213/2/7

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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