Elevated serum adiponectin level in patients with mycobacterium avium-intracellulare complex pulmonary disease

Sadatomo Tasaka, Naoki Hasegawa, Tomoyasu Nishimura, Wakako Yamasawa, Hirofumi Kamata, Hiromi Shinoda, Yoshifumi Kimizuka, Hiroshi Fujiwara, Hiroshi Hirose, Akitoshi Ishizaka

研究成果: Article

22 引用 (Scopus)

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Background: Patients with Mycobacterium avium-intracellulare complex (MAC) pulmonary disease often suffer from weight loss. Adipokines are factors secreted by adipocytes, including leptin and adiponectin, as well as some inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Body mass index (BMI) is known to be inversely correlated with adiponectin and positively with leptin, TNF-α, and IL-6. Objective: We aimed to evaluate the levels of serum adipokines, including adiponectin, leptin, TNF-α, and IL-6 in patients with MAC pulmonary disease. Methods: Forty consecutive patients with MAC pulmonary disease (8 males; median age 62 years; median BMI 18.1) were examined. Serum levels of adiponectin, leptin, TNF-α, and IL-6 were measured with ELISA. Age-, sex- and BMI-matched healthy subjects served as controls. Results: Serum adiponectin was significantly elevated in patients with MAC pulmonary disease compared with the controls (p < 0.01). In both the patients and controls, serum adiponectin levels were inversely correlated with BMI (p < 0.05). No significant correlation was observed between serum adiponectin levels and C-reactive protein or lung function. Serum leptin levels, which were positively correlated with BMI, did not differ between patients and controls. Serum levels of TNF-α and IL-6 were significantly greater in patients with MAC pulmonary disease than in controls. The levels of TNF-α and IL-6 were not correlated with BMI and other adipokines examined. Conclusion: The results of the present study indicate that, in patients with MAC pulmonary disease, adiponectin is inappropriately secreted and may play a role in the pathophysiology of the disease.

元の言語English
ページ(範囲)383-387
ページ数5
ジャーナルRespiration
79
発行部数5
DOI
出版物ステータスPublished - 2010 4

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Mycobacterium avium Complex
Adiponectin
Lung Diseases
Leptin
Interleukin-6
Body Mass Index
Tumor Necrosis Factor-alpha
Serum
Adipokines
Adipocytes
C-Reactive Protein
Weight Loss
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
Cytokines
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

これを引用

Elevated serum adiponectin level in patients with mycobacterium avium-intracellulare complex pulmonary disease. / Tasaka, Sadatomo; Hasegawa, Naoki; Nishimura, Tomoyasu; Yamasawa, Wakako; Kamata, Hirofumi; Shinoda, Hiromi; Kimizuka, Yoshifumi; Fujiwara, Hiroshi; Hirose, Hiroshi; Ishizaka, Akitoshi.

:: Respiration, 巻 79, 番号 5, 04.2010, p. 383-387.

研究成果: Article

Tasaka, Sadatomo ; Hasegawa, Naoki ; Nishimura, Tomoyasu ; Yamasawa, Wakako ; Kamata, Hirofumi ; Shinoda, Hiromi ; Kimizuka, Yoshifumi ; Fujiwara, Hiroshi ; Hirose, Hiroshi ; Ishizaka, Akitoshi. / Elevated serum adiponectin level in patients with mycobacterium avium-intracellulare complex pulmonary disease. :: Respiration. 2010 ; 巻 79, 番号 5. pp. 383-387.
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abstract = "Background: Patients with Mycobacterium avium-intracellulare complex (MAC) pulmonary disease often suffer from weight loss. Adipokines are factors secreted by adipocytes, including leptin and adiponectin, as well as some inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Body mass index (BMI) is known to be inversely correlated with adiponectin and positively with leptin, TNF-α, and IL-6. Objective: We aimed to evaluate the levels of serum adipokines, including adiponectin, leptin, TNF-α, and IL-6 in patients with MAC pulmonary disease. Methods: Forty consecutive patients with MAC pulmonary disease (8 males; median age 62 years; median BMI 18.1) were examined. Serum levels of adiponectin, leptin, TNF-α, and IL-6 were measured with ELISA. Age-, sex- and BMI-matched healthy subjects served as controls. Results: Serum adiponectin was significantly elevated in patients with MAC pulmonary disease compared with the controls (p < 0.01). In both the patients and controls, serum adiponectin levels were inversely correlated with BMI (p < 0.05). No significant correlation was observed between serum adiponectin levels and C-reactive protein or lung function. Serum leptin levels, which were positively correlated with BMI, did not differ between patients and controls. Serum levels of TNF-α and IL-6 were significantly greater in patients with MAC pulmonary disease than in controls. The levels of TNF-α and IL-6 were not correlated with BMI and other adipokines examined. Conclusion: The results of the present study indicate that, in patients with MAC pulmonary disease, adiponectin is inappropriately secreted and may play a role in the pathophysiology of the disease.",
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T1 - Elevated serum adiponectin level in patients with mycobacterium avium-intracellulare complex pulmonary disease

AU - Tasaka, Sadatomo

AU - Hasegawa, Naoki

AU - Nishimura, Tomoyasu

AU - Yamasawa, Wakako

AU - Kamata, Hirofumi

AU - Shinoda, Hiromi

AU - Kimizuka, Yoshifumi

AU - Fujiwara, Hiroshi

AU - Hirose, Hiroshi

AU - Ishizaka, Akitoshi

PY - 2010/4

Y1 - 2010/4

N2 - Background: Patients with Mycobacterium avium-intracellulare complex (MAC) pulmonary disease often suffer from weight loss. Adipokines are factors secreted by adipocytes, including leptin and adiponectin, as well as some inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Body mass index (BMI) is known to be inversely correlated with adiponectin and positively with leptin, TNF-α, and IL-6. Objective: We aimed to evaluate the levels of serum adipokines, including adiponectin, leptin, TNF-α, and IL-6 in patients with MAC pulmonary disease. Methods: Forty consecutive patients with MAC pulmonary disease (8 males; median age 62 years; median BMI 18.1) were examined. Serum levels of adiponectin, leptin, TNF-α, and IL-6 were measured with ELISA. Age-, sex- and BMI-matched healthy subjects served as controls. Results: Serum adiponectin was significantly elevated in patients with MAC pulmonary disease compared with the controls (p < 0.01). In both the patients and controls, serum adiponectin levels were inversely correlated with BMI (p < 0.05). No significant correlation was observed between serum adiponectin levels and C-reactive protein or lung function. Serum leptin levels, which were positively correlated with BMI, did not differ between patients and controls. Serum levels of TNF-α and IL-6 were significantly greater in patients with MAC pulmonary disease than in controls. The levels of TNF-α and IL-6 were not correlated with BMI and other adipokines examined. Conclusion: The results of the present study indicate that, in patients with MAC pulmonary disease, adiponectin is inappropriately secreted and may play a role in the pathophysiology of the disease.

AB - Background: Patients with Mycobacterium avium-intracellulare complex (MAC) pulmonary disease often suffer from weight loss. Adipokines are factors secreted by adipocytes, including leptin and adiponectin, as well as some inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Body mass index (BMI) is known to be inversely correlated with adiponectin and positively with leptin, TNF-α, and IL-6. Objective: We aimed to evaluate the levels of serum adipokines, including adiponectin, leptin, TNF-α, and IL-6 in patients with MAC pulmonary disease. Methods: Forty consecutive patients with MAC pulmonary disease (8 males; median age 62 years; median BMI 18.1) were examined. Serum levels of adiponectin, leptin, TNF-α, and IL-6 were measured with ELISA. Age-, sex- and BMI-matched healthy subjects served as controls. Results: Serum adiponectin was significantly elevated in patients with MAC pulmonary disease compared with the controls (p < 0.01). In both the patients and controls, serum adiponectin levels were inversely correlated with BMI (p < 0.05). No significant correlation was observed between serum adiponectin levels and C-reactive protein or lung function. Serum leptin levels, which were positively correlated with BMI, did not differ between patients and controls. Serum levels of TNF-α and IL-6 were significantly greater in patients with MAC pulmonary disease than in controls. The levels of TNF-α and IL-6 were not correlated with BMI and other adipokines examined. Conclusion: The results of the present study indicate that, in patients with MAC pulmonary disease, adiponectin is inappropriately secreted and may play a role in the pathophysiology of the disease.

KW - Adiponectin

KW - Body mass

KW - Leptin

KW - Mycobacterium avium-intracellulare complex

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