Elevated serum adiponectin level in patients with mycobacterium avium-intracellulare complex pulmonary disease

Sadatomo Tasaka, Naoki Hasegawa, Tomoyasu Nishimura, Wakako Yamasawa, Hirofumi Kamata, Hiromi Shinoda, Yoshifumi Kimizuka, Hiroshi Fujiwara, Hiroshi Hirose, Akitoshi Ishizaka

研究成果: Article

23 引用 (Scopus)

抜粋

Background: Patients with Mycobacterium avium-intracellulare complex (MAC) pulmonary disease often suffer from weight loss. Adipokines are factors secreted by adipocytes, including leptin and adiponectin, as well as some inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Body mass index (BMI) is known to be inversely correlated with adiponectin and positively with leptin, TNF-α, and IL-6. Objective: We aimed to evaluate the levels of serum adipokines, including adiponectin, leptin, TNF-α, and IL-6 in patients with MAC pulmonary disease. Methods: Forty consecutive patients with MAC pulmonary disease (8 males; median age 62 years; median BMI 18.1) were examined. Serum levels of adiponectin, leptin, TNF-α, and IL-6 were measured with ELISA. Age-, sex- and BMI-matched healthy subjects served as controls. Results: Serum adiponectin was significantly elevated in patients with MAC pulmonary disease compared with the controls (p < 0.01). In both the patients and controls, serum adiponectin levels were inversely correlated with BMI (p < 0.05). No significant correlation was observed between serum adiponectin levels and C-reactive protein or lung function. Serum leptin levels, which were positively correlated with BMI, did not differ between patients and controls. Serum levels of TNF-α and IL-6 were significantly greater in patients with MAC pulmonary disease than in controls. The levels of TNF-α and IL-6 were not correlated with BMI and other adipokines examined. Conclusion: The results of the present study indicate that, in patients with MAC pulmonary disease, adiponectin is inappropriately secreted and may play a role in the pathophysiology of the disease.

元の言語English
ページ(範囲)383-387
ページ数5
ジャーナルRespiration
79
発行部数5
DOI
出版物ステータスPublished - 2010 4 1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

フィンガープリント Elevated serum adiponectin level in patients with mycobacterium avium-intracellulare complex pulmonary disease' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用