Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation

Yosuke Isobe, Taiga Kato, Makoto Arita

研究成果: Review article査読

58 被引用数 (Scopus)

抄録

Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programs that enable inflamed tissues to return to homeostasis. The mechanisms by which acute inflammation is resolved are of interest, and research in recent years has uncovered new endogenous anti-inflammatory and proresolving lipid mediators (i.e., lipoxins, resolvins, protectin, and maresin) generated from polyunsaturated fatty acids (PUFAs).This review presents new insights into the cellular and molecular mechanisms of inflammatory resolution, especially the roles of eosinophils, and a series of omega-3 PUFA-derived anti-inflammatory lipid mediators that they generate.

本文言語English
論文番号Article 270
ジャーナルFrontiers in Immunology
3
AUG
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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