Enantioselective borohydride reduction catalyzed by optically active cobalt complexes

Tohru Yamada, Takushi Nagata, Kiyoaki D. Sugi, Kiyotaka Yorozu, Taketo Ikeno, Yuhki Ohtsuka, Daichi Miyazaki, Teruaki Mukaiyama

研究成果: Article

85 引用 (Scopus)

抜粋

The highly enantioselective borohydride reduction of aromatic ketones or imines to the corresponding alcohols was developed in the presence of a catalytic amount of an optically active cobalt(II) complex catalyst. This enantioselective reduction is carried out using a precisely premodified borohydride with alcohols such as tetrahydrofurfuryl alcohol, ethanol and methanol. High optical yields are obtained by choosing the appropriate alcohol as modifiers and a suitable β-ketoiminato ligand of the catalyst. The enantioselective borohydride reduction has been successfully applied to the preparation of optically active 1,3-diols, the stereoselective reduction of diacylferrocenes, and dynamic and/or kinetic resolution of 1,3-dicarbonyl compounds.

元の言語English
ページ(範囲)4485-4509
ページ数25
ジャーナルChemistry - A European Journal
9
発行部数18
DOI
出版物ステータスPublished - 2003 9 22

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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    Yamada, T., Nagata, T., Sugi, K. D., Yorozu, K., Ikeno, T., Ohtsuka, Y., Miyazaki, D., & Mukaiyama, T. (2003). Enantioselective borohydride reduction catalyzed by optically active cobalt complexes. Chemistry - A European Journal, 9(18), 4485-4509. https://doi.org/10.1002/chem.200304794