Enantioselective borohydride reduction of aliphatic ketones catalyzed by ketoiminatocobalt(iii) complex with 1-chlorovinyl axial ligand

Tatsuyuki Tsubo, Hsiu Hui Chen, Minako Yokomori, Kosuke Fukui, Satoshi Kikuchi, Tohru Yamada

研究成果: Article査読

11 被引用数 (Scopus)

抄録

For the enantioselective borohydride reduction of aliphatic ketones, the optically active ketoiminatocobalt(II) catalysts was successfully designed based on their axial ligand. Instead of chloroform for the aryl ketone reduction, various axial ligand precursors were examined for the aliphatic ketone. Consequently, 1, 1, 1-trichloroethane was found to be the most effective activator of the cobalt(II) complexes to generate the corresponding 1-chlorovinyl cobalt(III) derivatives as the reactive intermediate. Several aliphatic ketones were successfully reduced to afford the corresponding secondary alcohols with high enantioselectivities.

本文言語English
ページ(範囲)780-782
ページ数3
ジャーナルChemistry Letters
41
8
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • 化学 (全般)

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