Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacterium Alcaligenesbronchisepticus KU 1201

Kenji Miyamoto, Hiromichi Ohta

研究成果: Article査読

24 被引用数 (Scopus)

抄録

The metabolic pathway of phenylmalonic acid by Alcaligenesbronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of α-aryl-α-methylmalonic acids to α-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (±)-mandelic acid with A.bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids.

本文言語English
ページ(範囲)363-366
ページ数4
ジャーナルBiotechnology Letters
14
5
DOI
出版ステータスPublished - 1992 5 1

ASJC Scopus subject areas

  • バイオテクノロジー
  • バイオエンジニアリング
  • 応用微生物学とバイオテクノロジー

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