Enantioselective stereodivergent approach to α-hydroxy skipped dienes: Synthesis of the western polyene fragment of corallopyronin A

Yoshiyuki Nagashima, Yuto Okada, Takaaki Sato, Noritaka Chida

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Synthesis of the western polyene fragment of corallopyronin A is documented. The α-hydroxy skipped diene structure is stereoselectively synthesized by our method consisting of enantioselective allenylation of an aldehyde, hydroboration of the resulting 1, 1-disubstituted allene and Migita-Kosugi-Stille coupling. The developed approach could become a general platform for α-hydroxy skipped dienes embedded in a number of biologically active natural products because all eight stereoisomers of the α-hydroxy skipped diene are potentially available from the same aldehyde through these three stereodivergent reactions.

本文言語English
ページ(範囲)1519-1521
ページ数3
ジャーナルChemistry Letters
48
12
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • 化学 (全般)

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