抄録
(Chemical Equation Presented) A pseudo-1,4′-N-linked disaccharide, pseudoacarviosin 5, was constructed via a key palladium-catalyzed coupling reaction of pseudoglycosyl chloride 8 (prepared from d-glucose via a novel direct intramolecular aldol addition in 12 steps) and pseudo-4-amino-4,6- dideoxy-α-d-glucose 9 (prepared from l-arabinose via an unusual trans-fused isoxazolidine-selective intramolecular nitrone-alkene cycloaddition in 11 steps). Pseudoacarviosin 5 has been shown to be a potent inhibitor of α-glucosidases, particularly the intestinal mucosal enzymes sucrase and glucoamylase of relevance to blood glucose control.
本文言語 | English |
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ページ(範囲) | 3145-3148 |
ページ数 | 4 |
ジャーナル | Organic Letters |
巻 | 10 |
号 | 14 |
DOI | |
出版ステータス | Published - 2008 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学