抜粋
(Chemical Equation Presented) A pseudo-1,4′-N-linked disaccharide, pseudoacarviosin 5, was constructed via a key palladium-catalyzed coupling reaction of pseudoglycosyl chloride 8 (prepared from d-glucose via a novel direct intramolecular aldol addition in 12 steps) and pseudo-4-amino-4,6- dideoxy-α-d-glucose 9 (prepared from l-arabinose via an unusual trans-fused isoxazolidine-selective intramolecular nitrone-alkene cycloaddition in 11 steps). Pseudoacarviosin 5 has been shown to be a potent inhibitor of α-glucosidases, particularly the intestinal mucosal enzymes sucrase and glucoamylase of relevance to blood glucose control.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 3145-3148 |
| ページ数 | 4 |
| ジャーナル | Organic Letters |
| 巻 | 10 |
| 発行部数 | 14 |
| DOI | |
| 出版物ステータス | Published - 2008 1 1 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
フィンガープリント Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Shing, T. K. M., Cheng, H. M., Wong, W. F., Kwong, C. S. K., Li, J., Lau, C. B. S., Po, S. L., & Cheng, C. H. K. (2008). Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent. Organic Letters, 10(14), 3145-3148. https://doi.org/10.1021/ol8010503