抄録
Recent studies have suggested the existence of progenitors common to hematopoietic and endothelial cells, called hemangioblasts, in, for instance, embryonic dorsal aorta. To identify a membrane-bound or secretory molecule regulating early hematopoiesis, we screened a cDNA library from dorsal aortas of embryonic day (E) 10.5 mice by a signal sequence trap method and obtained a clone encoding a sialoprotein, endomucin-1. Immunohistochemistry revealed that the endomucin-1 transcript was specifically expressed in the endothelial cells of dorsal aorta of E10.5 mouse embryo. Overexpression of endomucin-1 strongly inhibited adhesion and aggregation of cells, including cultured endothelial cells from E10.5 dorsal aorta. These data suggest that endomucin-1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis.
本文言語 | English |
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ページ(範囲) | 501-506 |
ページ数 | 6 |
ジャーナル | Biochemical and Biophysical Research Communications |
巻 | 287 |
号 | 2 |
DOI | |
出版ステータス | Published - 2001 9月 21 |
外部発表 | はい |
ASJC Scopus subject areas
- 生物理学
- 生化学
- 分子生物学
- 細胞生物学