Endothelial Chemical Reaction and Drug Test Reproduced on Molded Flexible Collagen Hydrogel Tube

Shun Itai, Hiroaki Onoe

研究成果: Conference contribution

抄録

We reproduce chemical reactions of blood vessels by a flexibly deformable collagen tube device. The device is composed of an unfixed collagen hydrogel tube, enabling the reproduction of both macro and micro scale deformation of the vessel tissue. In addition, the device is easily perfused because the collagen hydrogel tube is directly attached to silicone tubes. We succeeded in demonstrating the chemical deformation of vessel tissue and endothelial cells by inflammatory mediators. Moreover, the drug testing was presented by anti-inflammatory chemicals. We believe that our flexible culturing device could help the construction of functional blood vessels reproducing in vivo chemical reactions in high similarity, and contribute to biomedical researches and pharmacokinetic testing.

本文言語English
ホスト出版物のタイトル21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
出版社Institute of Electrical and Electronics Engineers Inc.
ページ283-286
ページ数4
ISBN(電子版)9781665412674
DOI
出版ステータスPublished - 2021 6月 20
イベント21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 - Virtual, Online, United States
継続期間: 2021 6月 202021 6月 25

出版物シリーズ

名前21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

Conference

Conference21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
国/地域United States
CityVirtual, Online
Period21/6/2021/6/25

ASJC Scopus subject areas

  • 電子工学および電気工学
  • 機械工学
  • 制御と最適化
  • 器械工学

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