TY - JOUR
T1 - Endothelin-1 level in epithelial lining fluid of patients with acute respiratory distress syndrome
AU - Nakano, Yasushi
AU - Tasaka, Sadatomo
AU - Saito, Fumitake
AU - Yamada, Wakako
AU - Shiraishi, Yoshiki
AU - Ogawa, Yuko
AU - Koh, Hidefumi
AU - Hasegawa, Naoki
AU - Fujishima, Seitaro
AU - Hashimoto, Satoru
AU - Ishizaka, Akitoshi
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Background and objectives: Endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by endothelial cells, has been implicated in the dysfunction of various organs. To determine the role of ET-1 in acute lung injury (ALI) and ARDS, ET-1 levels were measured in epithelial lining fluid (ELF) and plasma obtained from patients with ALI/ARDS. Methods: A cross-sectional study of patients with ALI/ARDS in the intensive care unit of two university hospitals was performed. Patients with ALI/ARDS underwent bronchoscopic microsampling to collect ELF on the day of onset of the disease. Patients who underwent bronchoscopy to examine a small peripheral pulmonary nodule served as controls. Results: In the 23 patients with ALI/ARDS, the ET-1 level in ELF was significantly greater than that in plasma (P < 0.001). In contrast, ET-1 was not detectable in the ELF from six of the seven control subjects. The albumin concentration of ELF, used as a marker of endothelial and epithelial permeability, correlated with the ET-1 level in ELF (P < 0.001). The oxygenation index (PaO2/FiO2) was also correlated with ET-1 concentration in ELF (P < 0.001). Conclusion: In patients with ALI/ARDS, ET-1 is produced mainly in the lung and is associated not only with pulmonary vasoconstriction but also the development of permeability oedema, leading to the impairment of oxygenation.
AB - Background and objectives: Endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by endothelial cells, has been implicated in the dysfunction of various organs. To determine the role of ET-1 in acute lung injury (ALI) and ARDS, ET-1 levels were measured in epithelial lining fluid (ELF) and plasma obtained from patients with ALI/ARDS. Methods: A cross-sectional study of patients with ALI/ARDS in the intensive care unit of two university hospitals was performed. Patients with ALI/ARDS underwent bronchoscopic microsampling to collect ELF on the day of onset of the disease. Patients who underwent bronchoscopy to examine a small peripheral pulmonary nodule served as controls. Results: In the 23 patients with ALI/ARDS, the ET-1 level in ELF was significantly greater than that in plasma (P < 0.001). In contrast, ET-1 was not detectable in the ELF from six of the seven control subjects. The albumin concentration of ELF, used as a marker of endothelial and epithelial permeability, correlated with the ET-1 level in ELF (P < 0.001). The oxygenation index (PaO2/FiO2) was also correlated with ET-1 concentration in ELF (P < 0.001). Conclusion: In patients with ALI/ARDS, ET-1 is produced mainly in the lung and is associated not only with pulmonary vasoconstriction but also the development of permeability oedema, leading to the impairment of oxygenation.
KW - Acute respiratory distress syndrome
KW - Bronchoscopic microsampling
KW - Endothelin-1
KW - Epithelial lining fluid
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U2 - 10.1111/j.1440-1843.2007.01115.x
DO - 10.1111/j.1440-1843.2007.01115.x
M3 - Article
C2 - 17875064
AN - SCOPUS:34548688200
SN - 1323-7799
VL - 12
SP - 740
EP - 743
JO - Respirology
JF - Respirology
IS - 5
ER -