Cytokines and cytokine-induced nitric oxide (NO) play important roles in inflammatory glomerular diseases, and both platelet-derived growth factor and transforming growth factor-β inhibit cytokine-induced NO production. In this study, we demonstrated that a selective endothelin ET(A) receptor antagonist, BQ-485 (Hexahydro-1H-azepinylcarbonyl-Leu-d-Trp-d-Trp-OH), reversed the inhibitory effect of platelet-derived growth factor on cytokine-induced NO production, but not that of transforming growth factor-β. Our findings suggest a difference between the inhibitory mechanisms of platelet-derived growth factor and transforming growth factor-β on cytokine-induced NO production. Copyright (C) 1999 Elsevier Science B.V.
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