TY - JOUR
T1 - Endothelin ET(A) receptor antagonist reverses the inhibitory effect of platelet-derived growth factor on cytokine-induced nitric oxide production
AU - Hirahashi, Junichi
AU - Nakaki, Toshio
AU - Hishikawa, Keiichi
AU - Marumo, Takeshi
AU - Hayashi, Matsuhiko
AU - Saruta, Takao
N1 - Funding Information:
This work was supported in part by grant-in-aid from the Ministry of Education, Science and Culture of Japan and a Grant for Scientific Research Expenses for Health and Welfare Programs; Funds for Comprehensive Research on Long-Term Chronic Disease (Renal Failure).
PY - 1999/1/15
Y1 - 1999/1/15
N2 - Cytokines and cytokine-induced nitric oxide (NO) play important roles in inflammatory glomerular diseases, and both platelet-derived growth factor and transforming growth factor-β inhibit cytokine-induced NO production. In this study, we demonstrated that a selective endothelin ET(A) receptor antagonist, BQ-485 (Hexahydro-1H-azepinylcarbonyl-Leu-d-Trp-d-Trp-OH), reversed the inhibitory effect of platelet-derived growth factor on cytokine-induced NO production, but not that of transforming growth factor-β. Our findings suggest a difference between the inhibitory mechanisms of platelet-derived growth factor and transforming growth factor-β on cytokine-induced NO production. Copyright (C) 1999 Elsevier Science B.V.
AB - Cytokines and cytokine-induced nitric oxide (NO) play important roles in inflammatory glomerular diseases, and both platelet-derived growth factor and transforming growth factor-β inhibit cytokine-induced NO production. In this study, we demonstrated that a selective endothelin ET(A) receptor antagonist, BQ-485 (Hexahydro-1H-azepinylcarbonyl-Leu-d-Trp-d-Trp-OH), reversed the inhibitory effect of platelet-derived growth factor on cytokine-induced NO production, but not that of transforming growth factor-β. Our findings suggest a difference between the inhibitory mechanisms of platelet-derived growth factor and transforming growth factor-β on cytokine-induced NO production. Copyright (C) 1999 Elsevier Science B.V.
KW - Endothelin ET(A) receptor
KW - Mesangial cells
KW - Nitric oxide (NO)
KW - Platelet-derived growth factor
KW - Transforming growth factor-β
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U2 - 10.1016/S0014-2999(98)00849-8
DO - 10.1016/S0014-2999(98)00849-8
M3 - Article
C2 - 9988130
AN - SCOPUS:0033556392
SN - 0014-2999
VL - 365
SP - 119
EP - 123
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -