Endothelin-l-Induced Phosphorylation of the 20-kDa Myosin Light Chain and Caldesmon in Porcine Coronary Artery Smooth Muscle

Yoichiro Abe, Michiyo Kudo, Kamejiro Yamashita, Yoh Takuwa, Katsutoshi Goto, Tomoh Masaki

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Endothelin-1 (ET), a potent vasoconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips. ET also induces late phosphorylation of caldesmon, which is mimicked by 12-deoxyphorbol 13-isobutyrate, but not by 60 mM KC1. Nitroglycerin, a vasorelaxant, completely reverses the ET-induced phosphorylation of MLC, but not that of caldesmon. These results suggest an important regulatory role of MLC phosphorylation in ET-induced contraction.

本文言語English
ページ(範囲)431-435
ページ数5
ジャーナルThe Japanese Journal of Pharmacology
57
3
DOI
出版ステータスPublished - 1991 1
外部発表はい

ASJC Scopus subject areas

  • Pharmacology

フィンガープリント 「Endothelin-l-Induced Phosphorylation of the 20-kDa Myosin Light Chain and Caldesmon in Porcine Coronary Artery Smooth Muscle」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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