Endothelin Potentiates Growth Factor‐stimulated DNA Synthesis in Swiss 3T3 Cells

Masatoshi Kusuhara, Ken Yamaguchi, Ai Ohnishi, Kaoru Abe, Satoshi Kimura, Hideto Oono, Shingo Hori, Yoshiro Nakamura

研究成果: Article査読

49 被引用数 (Scopus)

抄録

A murine cell line, Swiss 3T3, is commonly used for the study of cellular growth. The present study revealed that this cell line possesses high‐affinity receptors for endothelin, a vasoactive peptide derived from vascular endothelial cells. In this cell line, endothelin potentiated DNA synthesis stimulated by platelet‐derived growth factor, basic fibroblast growth factor or insulin. The endothelin concentration required for potentiating DNA synthesis in this cell line is almost the same as that reported previously in endothelin‐induced vasoconstriction. Since endothelin increased intracellular calcium levels, this ion may participate in the signal transduction pathways by which endothelin induces potentiation of DNA synthesis.

本文言語English
ページ(範囲)302-305
ページ数4
ジャーナルJapanese Journal of Cancer Research
80
4
DOI
出版ステータスPublished - 1989 4

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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