Engineering principles of synthetic biochemical oscillators with negative cyclic feedback

Yutaka Hori, Richard M. Murray

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

This paper analyzes oscillatory dynamics of a class of cyclic gene regulatory networks and provides engineering principles for the synthesis of biochemical oscillators. We first review previous results that the oscillatory parameter regime of the gene regulatory circuits can be rigorously explored by the local stability analysis of a unique equilibrium. The local stability analysis then leads to the first engineering principle that the circuit components, or genes, should be chosen so that the kinetic profiles of the circuit components are similar to each other. Using a homogeneous oscillator model, we further discuss design strategies to reduce the cell-to-cell variability of the oscillators that is caused by intrinsic noise.

本文言語English
ホスト出版物のタイトル54rd IEEE Conference on Decision and Control,CDC 2015
出版社Institute of Electrical and Electronics Engineers Inc.
ページ584-589
ページ数6
ISBN(電子版)9781479978861
DOI
出版ステータスPublished - 2015 2 8
外部発表はい
イベント54th IEEE Conference on Decision and Control, CDC 2015 - Osaka, Japan
継続期間: 2015 12 152015 12 18

出版物シリーズ

名前Proceedings of the IEEE Conference on Decision and Control
54rd IEEE Conference on Decision and Control,CDC 2015
ISSN(印刷版)0743-1546

Other

Other54th IEEE Conference on Decision and Control, CDC 2015
CountryJapan
CityOsaka
Period15/12/1515/12/18

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Modelling and Simulation
  • Control and Optimization

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