Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori

Hitoshi Tsugawa, Hidekazu Suzuki, Hiroe Muraoka, Fumiaki Ikeda, Kenro Hirata, Juntaro Matsuzaki, Yoshimasa Saito, Toshifumi Hibi

研究成果: Article

29 引用 (Scopus)

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Although metronidazole (Mtz) is an important component of Helicobacter pylori eradication regimens, it has been pointed out that the increasing use of Mtz may result in increase in the incidence of Mtz-resistant strains. The present study was designed to examine the initial mechanism of resistance acquisition of H. pylori to Mtz. After 10 Mtz-susceptible strains were cultured on plates containing sub-inhibitory concentrations of Mtz, the MIC of Mtz for 9 of the 10 strains increased to levels of the Mtz-resistant strains. In the Mtz-resistance-induced strains, the expression of the TolC efflux pump (hefA) was significantly increased under Mtz exposure, without the reduction of the Mtz-reductive activity. Our finding suggests that overexpression of hefA may be the initial step in the acquisition of Mtz resistance in H. pylori.

元の言語English
ページ(範囲)656-660
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
404
発行部数2
DOI
出版物ステータスPublished - 2011 1 14

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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