Enhanced cortical blood plow during selective stimulation of sensory or postganglionic parasympathetic cerebrovascular nerve fibers in rats: Possible role of putative transmitters

Norihiro Suzuki, Jan Erik Hardebo, Christer Owman

研究成果: Article査読

1 被引用数 (Scopus)

抄録

In order to clarify the functional role of the cerebrovascular parasympathetic and sensory nerves on the vessel tone in vivo, and the transmitters responsible for such an effect, brain cortical microvascular blood flow was measured in rats during electrical stimulation of these particular postganglionic parasympathetic and sensory fibers. Their respective central connections were cut prior to stimulation, to avoid cerebral flow changes sencondary to activation of central structures. Relative changes in microvascular blood flow was continuously recorded by a laser-Doppler flowmeter system under cc-chloralose or ketamine anesthesia. Stimulation of the postganglionic parasympathetic fibers induced a marked increase in the cortical blood flow on the ipsilateral side, whereas no change was observed on the contralateral side. Atropine and scopolamine, applied locally or systemically in effective concentrations, failed to alter the flow increase upon parasympathetic stimulation. The strong vasodilator vasoactive intestinal polypeptide found in these nerves remains as a possible transmitter responsible for the flow increase, although a proposed antagonist tested did not attenuate the response. The modest flow increase seen ipsilaterally upon stimulation of the sensory nerve fibers is likely to be caused by antidromic release of transmitter in pain fibers. Antagonists to substance P did not affect the response. The strong vasodilator in these nerves, calcitonin generelated peptide, is a possible candidate responsible for the flow increase.

本文言語English
ページ(範囲)35-43
ページ数9
ジャーナルBiomedical Research (Japan)
11
1
DOI
出版ステータスPublished - 1990 1月 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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