Enhanced fluorescent DNA microarray using optical interference mirror slide

Mitsuru Yasuda, Takuo Akimoto

研究成果: Article査読

抄録

Enhanced fluorescence using an optical interference mirror (OIM) slide consisting of a metal film and a transparent dielectric thin film is used to improve the sensitivity of a DNA microarray. Twenty-one bases of a probe DNA are immobilized on the OIM slide fabricated with Ag and Al2O3, and 21 bases of target DNA, whose sequence is complementary to that of the probe DNA, are detected. After evaluating the hybridization specificity between the probe DNA and the target DNA, the sensitivity improvement is estimated. As a result, a 50-fold improvement can be achieved compared with a bare glass slide.

本文言語English
ページ(範囲)59-66
ページ数8
ジャーナルSensors and Materials
30
1
DOI
出版ステータスPublished - 2018
外部発表はい

ASJC Scopus subject areas

  • 器械工学
  • 材料科学(全般)

フィンガープリント

「Enhanced fluorescent DNA microarray using optical interference mirror slide」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル