Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

Paul Kievit, Jane K. Howard, Michael K. Badman, Nina Balthasar, Roberto Coppari, Hiroyuki Mori, Charlotte E. Lee, Joel K. Elmquist, Akihiko Yoshimura, Jeffrey S. Flier

研究成果: Article

156 引用 (Scopus)

抄録

Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean and more leptin and insulin sensitive. To examine the role of Socs-3 within specific neurons critical to energy balance, we created mice with selective deletion of Socs-3 within pro-opiomelanocortin (POMC)-expressing cells. These mice had enhanced leptin sensitivity, measured by weight loss and food intake after leptin infusion. On chow diet, glucose homeostasis was improved despite normal weight gain. On a high-fat diet, the rate of weight gain was reduced, due to increased energy expenditure rather than decreased food intake; glucose homeostasis and insulin sensitivity were substantially improved. These studies demonstrate that Socs-3 within POMC neurons regulates leptin sensitivity and glucose homeostasis, and plays a key role in linking high-fat diet to disordered metabolism.

元の言語English
ページ(範囲)123-132
ページ数10
ジャーナルCell Metabolism
4
発行部数2
DOI
出版物ステータスPublished - 2006 8
外部発表Yes

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Pro-Opiomelanocortin
Leptin
Homeostasis
Cytokines
Glucose
High Fat Diet
Weight Gain
Eating
Insulin
Neurons
Haploinsufficiency
Energy Metabolism
Insulin Resistance
Weight Loss
Hormones
Diet

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

これを引用

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. / Kievit, Paul; Howard, Jane K.; Badman, Michael K.; Balthasar, Nina; Coppari, Roberto; Mori, Hiroyuki; Lee, Charlotte E.; Elmquist, Joel K.; Yoshimura, Akihiko; Flier, Jeffrey S.

:: Cell Metabolism, 巻 4, 番号 2, 08.2006, p. 123-132.

研究成果: Article

Kievit, P, Howard, JK, Badman, MK, Balthasar, N, Coppari, R, Mori, H, Lee, CE, Elmquist, JK, Yoshimura, A & Flier, JS 2006, 'Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells', Cell Metabolism, 巻. 4, 番号 2, pp. 123-132. https://doi.org/10.1016/j.cmet.2006.06.010
Kievit, Paul ; Howard, Jane K. ; Badman, Michael K. ; Balthasar, Nina ; Coppari, Roberto ; Mori, Hiroyuki ; Lee, Charlotte E. ; Elmquist, Joel K. ; Yoshimura, Akihiko ; Flier, Jeffrey S. / Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. :: Cell Metabolism. 2006 ; 巻 4, 番号 2. pp. 123-132.
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