Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka; Hidekazu Suzuki; Hiroshi Hosoda; Takayuki Ota; Yuriko Minegishi; Hiroshi Nagata; Kenji Kangawa; Hiromasa Ishii

doi:10.1016/S0014-5793(03)00306-5

Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii

研究成果: Article › 査読

81 被引用数 (Scopus)

抄録

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

本文言語	English
ページ（範囲）	64-68
ページ数	5
ジャーナル	FEBS Letters
巻	541
号	1-3
DOI	https://doi.org/10.1016/S0014-5793(03)00306-5
出版ステータス	Published - 2003 4月 24

ASJC Scopus subject areas

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1016/S0014-5793(03)00306-5

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引用スタイル

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title = "Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes",

abstract = "Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.",

keywords = "Diabetes, Ghrelin, Growth hormone, Preproghrelin, Stomach",

author = "Tatsuhiro Masaoka and Hidekazu Suzuki and Hiroshi Hosoda and Takayuki Ota and Yuriko Minegishi and Hiroshi Nagata and Kenji Kangawa and Hiromasa Ishii",

note = "Funding Information: This study was supported by a Grant-in-Aid for Scientific Research C (No. 13670555: to H.S.) from the Japan Society for the Promotion of Science (JSPS) and by a Keio Gijyuku Academic Development Fund. The authors thank Dr. Sachiko Nomura and Miss Kumiko Kurabayashi, Center for Integrated Medical Research, School of Medicine, Keio University, for their technical assistance.",

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doi = "10.1016/S0014-5793(03)00306-5",

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T1 - Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

AU - Masaoka, Tatsuhiro

AU - Suzuki, Hidekazu

AU - Hosoda, Hiroshi

AU - Ota, Takayuki

AU - Minegishi, Yuriko

AU - Nagata, Hiroshi

AU - Kangawa, Kenji

AU - Ishii, Hiromasa

N1 - Funding Information: This study was supported by a Grant-in-Aid for Scientific Research C (No. 13670555: to H.S.) from the Japan Society for the Promotion of Science (JSPS) and by a Keio Gijyuku Academic Development Fund. The authors thank Dr. Sachiko Nomura and Miss Kumiko Kurabayashi, Center for Integrated Medical Research, School of Medicine, Keio University, for their technical assistance.

PY - 2003/4/24

Y1 - 2003/4/24

N2 - Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

AB - Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

KW - Diabetes

KW - Ghrelin

KW - Growth hormone

KW - Preproghrelin

KW - Stomach

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DO - 10.1016/S0014-5793(03)00306-5

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JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

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Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

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ASJC Scopus subject areas

UN SDG

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