Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii

研究成果: Article

78 引用 (Scopus)

抜粋

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

元の言語English
ページ(範囲)64-68
ページ数5
ジャーナルFEBS Letters
541
発行部数1-3
DOI
出版物ステータスPublished - 2003 4 24

    フィンガープリント

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

これを引用

Masaoka, T., Suzuki, H., Hosoda, H., Ota, T., Minegishi, Y., Nagata, H., Kangawa, K., & Ishii, H. (2003). Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes. FEBS Letters, 541(1-3), 64-68. https://doi.org/10.1016/S0014-5793(03)00306-5