Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii

研究成果: Article査読

81 被引用数 (Scopus)

抄録

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

本文言語English
ページ(範囲)64-68
ページ数5
ジャーナルFEBS Letters
541
1-3
DOI
出版ステータスPublished - 2003 4月 24

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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