Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka; Hidekazu Suzuki; Hiroshi Hosoda; Takayuki Ota; Yuriko Minegishi; Hiroshi Nagata; Kenji Kangawa; Hiromasa Ishii

doi:10.1016/S0014-5793(03)00306-5

Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii

研究成果: Article

78 引用（Scopus）

抜粋

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

元の言語	English
ページ（範囲）	64-68
ページ数	5
ジャーナル	FEBS Letters
巻	541
発行部数	1-3
DOI	https://doi.org/10.1016/S0014-5793(03)00306-5
出版物ステータス	Published - 2003 4 24

フィンガープリント

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

これを引用

Masaoka, T., Suzuki, H., Hosoda, H., Ota, T., Minegishi, Y., Nagata, H., Kangawa, K., & Ishii, H. (2003). Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes. FEBS Letters, 541(1-3), 64-68. https://doi.org/10.1016/S0014-5793(03)00306-5

@article{0c3373ad5b284d6a9f09451cec2adecd,

title = "Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes",

abstract = "Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.",

keywords = "Diabetes, Ghrelin, Growth hormone, Preproghrelin, Stomach",

author = "Tatsuhiro Masaoka and Hidekazu Suzuki and Hiroshi Hosoda and Takayuki Ota and Yuriko Minegishi and Hiroshi Nagata and Kenji Kangawa and Hiromasa Ishii",

year = "2003",

month = apr

day = "24",

doi = "10.1016/S0014-5793(03)00306-5",

language = "English",

volume = "541",

pages = "64--68",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

AU - Masaoka, Tatsuhiro

AU - Suzuki, Hidekazu

AU - Hosoda, Hiroshi

AU - Ota, Takayuki

AU - Minegishi, Yuriko

AU - Nagata, Hiroshi

AU - Kangawa, Kenji

AU - Ishii, Hiromasa

PY - 2003/4/24

Y1 - 2003/4/24

N2 - Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

AB - Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

KW - Diabetes

KW - Ghrelin

KW - Growth hormone

KW - Preproghrelin

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=0037464473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037464473&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(03)00306-5

DO - 10.1016/S0014-5793(03)00306-5

M3 - Article

C2 - 12706820

AN - SCOPUS:0037464473

VL - 541

SP - 64

EP - 68

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1-3

ER -

文献にアクセス

10.1016/S0014-5793(03)00306-5