@article{0c3373ad5b284d6a9f09451cec2adecd,
title = "Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes",
abstract = "Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.",
keywords = "Diabetes, Ghrelin, Growth hormone, Preproghrelin, Stomach",
author = "Tatsuhiro Masaoka and Hidekazu Suzuki and Hiroshi Hosoda and Takayuki Ota and Yuriko Minegishi and Hiroshi Nagata and Kenji Kangawa and Hiromasa Ishii",
note = "Funding Information: This study was supported by a Grant-in-Aid for Scientific Research C (No. 13670555: to H.S.) from the Japan Society for the Promotion of Science (JSPS) and by a Keio Gijyuku Academic Development Fund. The authors thank Dr. Sachiko Nomura and Miss Kumiko Kurabayashi, Center for Integrated Medical Research, School of Medicine, Keio University, for their technical assistance.",
year = "2003",
month = apr,
day = "24",
doi = "10.1016/S0014-5793(03)00306-5",
language = "English",
volume = "541",
pages = "64--68",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1-3",
}