Nerve growth factor (NGF)-induced neurite-outgrowth of PC12 cells was enhanced by polyoxometalates such as Na9[SbW9O 33] · 19.5H2O (SbW9) and (NH 3Pri)6[Mo7O24] · 3H2O (Mo7). Western blotting analysis of polyoxometalate/NGF-treated PC12 cells showed a strong expression of growth-associated protein 43 (GAP-43), which is associated with the neurite outgrowth. Similar effects were observed for other polyoxometalates, K 11H[(VO)3(SbW9O33)2] · 27H2O ((VO)3(SbW9)2), K6[P2W18O62] · 14H 2O (P2W18), and K7[PTi 2W10O40] · 6H2O (PTi 2W10), in contrast with little effect for monomeric tungstate and molybdate. Of the polyoxometalates tested in this study, SbW 9 and Mo7 were the most potent.
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