Enhancement effect of polyoxometalates on NGF-induced neurite-outgrowth of PC12 cells

Mayumi Oda; Miyao Inoue; Kazuyoshi Hino; Yukiko Nakamura; Toshihiro Yamase

doi:10.1248/bpb.30.787

Enhancement effect of polyoxometalates on NGF-induced neurite-outgrowth of PC12 cells

Mayumi Oda, Miyao Inoue, Kazuyoshi Hino, Yukiko Nakamura, Toshihiro Yamase

研究成果: Article › 査読

8 被引用数 (Scopus)

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Nerve growth factor (NGF)-induced neurite-outgrowth of PC12 cells was enhanced by polyoxometalates such as Na₉[SbW₉O ₃₃] · 19.5H₂O (SbW₉) and (NH ₃Prⁱ)₆[Mo₇O₂₄] · 3H₂O (Mo₇). Western blotting analysis of polyoxometalate/NGF-treated PC12 cells showed a strong expression of growth-associated protein 43 (GAP-43), which is associated with the neurite outgrowth. Similar effects were observed for other polyoxometalates, K ₁₁H[(VO)₃(SbW₉O₃₃)₂] · 27H₂O ((VO)₃(SbW₉)₂), K₆[P₂W₁₈O₆₂] · 14H ₂O (P₂W₁₈), and K₇[PTi ₂W₁₀O₄₀] · 6H₂O (PTi ₂W₁₀), in contrast with little effect for monomeric tungstate and molybdate. Of the polyoxometalates tested in this study, SbW ₉ and Mo₇ were the most potent.

本文言語	English
ページ（範囲）	787-790
ページ数	4
ジャーナル	Biological and Pharmaceutical Bulletin
巻	30
号	4
DOI	https://doi.org/10.1248/bpb.30.787
出版ステータス	Published - 2007 4月
外部発表	はい

ASJC Scopus subject areas

薬理学
薬科学

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10.1248/bpb.30.787

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title = "Enhancement effect of polyoxometalates on NGF-induced neurite-outgrowth of PC12 cells",

abstract = "Nerve growth factor (NGF)-induced neurite-outgrowth of PC12 cells was enhanced by polyoxometalates such as Na9[SbW9O 33] · 19.5H2O (SbW9) and (NH 3Pri)6[Mo7O24] · 3H2O (Mo7). Western blotting analysis of polyoxometalate/NGF-treated PC12 cells showed a strong expression of growth-associated protein 43 (GAP-43), which is associated with the neurite outgrowth. Similar effects were observed for other polyoxometalates, K 11H[(VO)3(SbW9O33)2] · 27H2O ((VO)3(SbW9)2), K6[P2W18O62] · 14H 2O (P2W18), and K7[PTi 2W10O40] · 6H2O (PTi 2W10), in contrast with little effect for monomeric tungstate and molybdate. Of the polyoxometalates tested in this study, SbW 9 and Mo7 were the most potent.",

keywords = "Nerve growth factor, Neurite-outgrowth, PC12 cell, Polyoxometalate",

author = "Mayumi Oda and Miyao Inoue and Kazuyoshi Hino and Yukiko Nakamura and Toshihiro Yamase",

year = "2007",

month = apr,

doi = "10.1248/bpb.30.787",

language = "English",

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journal = "Biological and Pharmaceutical Bulletin",

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TY - JOUR

T1 - Enhancement effect of polyoxometalates on NGF-induced neurite-outgrowth of PC12 cells

AU - Oda, Mayumi

AU - Inoue, Miyao

AU - Hino, Kazuyoshi

AU - Nakamura, Yukiko

AU - Yamase, Toshihiro

PY - 2007/4

Y1 - 2007/4

N2 - Nerve growth factor (NGF)-induced neurite-outgrowth of PC12 cells was enhanced by polyoxometalates such as Na9[SbW9O 33] · 19.5H2O (SbW9) and (NH 3Pri)6[Mo7O24] · 3H2O (Mo7). Western blotting analysis of polyoxometalate/NGF-treated PC12 cells showed a strong expression of growth-associated protein 43 (GAP-43), which is associated with the neurite outgrowth. Similar effects were observed for other polyoxometalates, K 11H[(VO)3(SbW9O33)2] · 27H2O ((VO)3(SbW9)2), K6[P2W18O62] · 14H 2O (P2W18), and K7[PTi 2W10O40] · 6H2O (PTi 2W10), in contrast with little effect for monomeric tungstate and molybdate. Of the polyoxometalates tested in this study, SbW 9 and Mo7 were the most potent.

AB - Nerve growth factor (NGF)-induced neurite-outgrowth of PC12 cells was enhanced by polyoxometalates such as Na9[SbW9O 33] · 19.5H2O (SbW9) and (NH 3Pri)6[Mo7O24] · 3H2O (Mo7). Western blotting analysis of polyoxometalate/NGF-treated PC12 cells showed a strong expression of growth-associated protein 43 (GAP-43), which is associated with the neurite outgrowth. Similar effects were observed for other polyoxometalates, K 11H[(VO)3(SbW9O33)2] · 27H2O ((VO)3(SbW9)2), K6[P2W18O62] · 14H 2O (P2W18), and K7[PTi 2W10O40] · 6H2O (PTi 2W10), in contrast with little effect for monomeric tungstate and molybdate. Of the polyoxometalates tested in this study, SbW 9 and Mo7 were the most potent.

KW - Nerve growth factor

KW - Neurite-outgrowth

KW - PC12 cell

KW - Polyoxometalate

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Enhancement effect of polyoxometalates on NGF-induced neurite-outgrowth of PC12 cells

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