Enhancement of CDP-DG: inositol transferase activity in src- and erbB2- transformed cells

Masaya Imoto, Yoshiko Taniguchi, Hiroaki Fujiwara, Kazuo Umezawa

研究成果: Article

8 引用 (Scopus)

抄録

Phosphatidylinositol (PI) synthesis was activated in Rous sarcoma virus- infected NIH3T3 or activated erbB2-transformed NIH3T3 cells. The in vitro activity of CDP-DG:inositol transferase prepared from these cells was also higher than that from normal parent NIH3T3 cells, although phospholipase C and PI kinase activities were not significantly different among these cells. A tyrosine kinase inhibitor, erbstatin, inhibited the PI synthesis in cultured cells, suggesting that Src and ErbB2-associated tyrosine kinases are involved in activation of CDP-DG:inositol transferase in these cell lines.

元の言語English
ページ(範囲)151-154
ページ数4
ジャーナルExperimental Cell Research
212
発行部数1
DOI
出版物ステータスPublished - 1994

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CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
Phosphatidylinositols
Protein-Tyrosine Kinases
Rous sarcoma virus
Type C Phospholipases
Cultured Cells
Phosphotransferases
Cell Line

ASJC Scopus subject areas

  • Cell Biology

これを引用

Enhancement of CDP-DG : inositol transferase activity in src- and erbB2- transformed cells. / Imoto, Masaya; Taniguchi, Yoshiko; Fujiwara, Hiroaki; Umezawa, Kazuo.

:: Experimental Cell Research, 巻 212, 番号 1, 1994, p. 151-154.

研究成果: Article

Imoto, Masaya ; Taniguchi, Yoshiko ; Fujiwara, Hiroaki ; Umezawa, Kazuo. / Enhancement of CDP-DG : inositol transferase activity in src- and erbB2- transformed cells. :: Experimental Cell Research. 1994 ; 巻 212, 番号 1. pp. 151-154.
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