@article{e24f6d84286046d1a6ee9388e7a69d61,
title = "Enrichment of type I interferon signaling in colonic group 2 innate lymphoid cells in experimental colitis",
abstract = "Group 2 innate lymphoid cells (ILC2s) serve as frontline defenses against parasites. However, excluding helminth infections, it is poorly understood how ILC2s function in intestinal inflammation, including inflammatory bowel disease. Here, we analyzed the global gene expression of ILC2s in healthy and colitic conditions and revealed that type I interferon (T1IFN)-stimulated genes were up-regulated in ILC2s in dextran sodium sulfate (DSS)-induced colitis. The enhancement of T1IFN signaling in ILC2s in DSS-induced colitis was correlated with the downregulation of cytokine production by ILC2s, such as interleukin-5. Blocking T1IFN signaling during colitis resulted in exaggeration of colitis in both wild-type and Rag2-deficient mice. The exacerbation of colitis induced by neutralization of T1IFN signaling was accompanied by reduction of amphiregulin (AREG) in ILC2s and was partially rescued by exogenous AREG treatment. Collectively, these findings show the potential roles of T1IFN in ILC2s that contribute to colitis manifestation.",
keywords = "ILC2 - group 2 innate lymphoid cell, colitis, ibd, ifnar, type I interferon",
author = "Emi Irie and Rino Ishihara and Ichiro Mizushima and Shunya Hatai and Yuya Hagihara and Yoshiaki Takada and Junya Tsunoda and Kentaro Iwata and Yuta Matsubara and Yusuke Yoshimatsu and Hiroki Kiyohara and Nobuhito Taniki and Tomohisa Sujino and Kaoru Takabayashi and Naoki Hosoe and Haruhiko Ogata and Toshiaki Teratani and Nobuhiro Nakamoto and Yohei Mikami and Takanori Kanai",
note = "Funding Information: This study was funded by the Japan Society for the Promotion of Science (JSPS) KAKENHI (B) 20H03666 to YoM, and (A) 20H00536 to TK; JSPS Grant-in-Aid for Transformative Research Areas(B): 21H05123 to YoM.; Advanced Research and Development Programs for Medical Innovation (AMED-CREST: 21gm1510002h0001to TK, and 20gm1210001h0001 to YM; the Practical Research Project for Rare/Intractable Disease: 21ek0109556h0001 to YM); the Japan Foundation for Applied Enzymology; and Keio University Medical Fund. Publisher Copyright: Copyright {\textcopyright} 2022 Irie, Ishihara, Mizushima, Hatai, Hagihara, Takada, Tsunoda, Iwata, Matsubara, Yoshimatsu, Kiyohara, Taniki, Sujino, Takabayashi, Hosoe, Ogata, Teratani, Nakamoto, Mikami and Kanai.",
year = "2022",
month = oct,
day = "4",
doi = "10.3389/fimmu.2022.982827",
language = "English",
volume = "13",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
}