Enzymatic kinetic resolution of cyanohydrin acetates and its application to the synthesis of (S)-(-)-frontalin

Hiromichi Ohta, Yoichi Kimura, Yasushi Sugano, Takeshi Sugai

研究成果: Article査読

59 被引用数 (Scopus)

抄録

Kinetic resolution of racemic 1-cyano-1-methylalkyl and alkenyl acetates has been achieved on incubation with Pichia miso IAM 4682, which hydolyzed selectively the (R)-enantiomer, leaving behind the (S)-enantiomer intact. The chiral 1-cyano-1-methyl-5-hexenyl acetate thus obtained was converted to (S)-(-)-frontalin via unsaturated diol.

本文言語English
ページ(範囲)5469-5476
ページ数8
ジャーナルTetrahedron
45
17
DOI
出版ステータスPublished - 1989

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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